業績

results

 研究面として、脂質プロファイル、脂質関連遺伝子や炎症ケモカインと循環器疾患との関連の研究、腎動脈交感神経デナベーション治療の臨床応用に関する研究、原発性アルドステロン症の局在診断の為の超選択的副腎静脈サンプリング検査における治療の研究、腎血管性高血圧症に関するカテーテル治療適応疾患の検索、循環器疾患でのヒト循環血中単核球キマーゼ依存アンジオテンシンⅡ活性の意義についての臨床研究、循環器臨床研究ネットワークでの多施設共同前向き観察試験研究の解析、旅行医学に関する研究を行ってきました。

 これまで原著22本{筆頭著者として和文0本、英文12本}発表、総説/letter5本{筆頭者として和文2本、英文3本}、症例報告11本{筆頭者として和文4本、英文4本}、学会発表{筆頭者として国内38回、国際16回}を報告しています。{2019年9月}

原著

First Author

 

Ratio of LDL- to HDL-associated platelet-activating factor acetylhydrolase may be a marker of inflammation in patients with paroxysmal atrial fibrillation.

Circ J. (2007, 71(2): 214-219)

Okamura, K. Miura, S. Zhang, B. Uehara, Y. Matsuo, K. Kumagai, K. Saku K.

 

Anti-hypertensive action and safety of candesartan / Hydrochlorothiazid combined drug in uncontrolled hypertensive patients: A prospective multicenter observational study (CHAT-E study)     

Therapeutic Research (2015, 36(5): 439-448)

Okamura, K. Urata, H. Chikushi Anti-Hypertension Trial-Ecard (CHAT-E)

 

Prevalence and Characteristics of Treatment-Resistant Hypertension among Hypertensive Japanese Outpatients.

International Journal of Clinical Medicine (2015, 6: 623-634)

Okamura, K. Urata, H.

 

Heart Rate and Blood Pressure Changes in Four Healthy Volunteers During Commercial Flight   

Therapeutic Research (2016, 37(12): 1167-1174)

Okamura, K, Okuda, T. Hiratsuka, Y. Shigekane, Y. Saruwatari, K. Urata, H.

 

Prospective direct comparison of antihypertensive effect and safety between high-dose amlodipine or indapamide in hypertensive patients uncontrolled by standard doses of angiotensin receptor blockers and amlodipine.  

Clin Exp Hypertens. (2018, 40(2): 99-106)

Okamura, K. Shirai, K. Totake, N. Okuda, T. Urata, H.

 

Positive correlation between blood pressure or heart rate and chymase-dependent angiotensin II-forming activity in circulating mononuclear leukocytes measured by new ELISA.          

Clin Exp Hypertens. (2018,40(2): 112-117)

Okamura, K. Okuda, T. Shirai, K. Urata, H.

 

The Prevalence of Japanese Outpatients with Hypertension Who Meet the Definition of Treatment Resistant Hypertension and Are Eligible for Enrolment in Clinical Trials of Endovascular Ultrasound Renal Denervation.                                                                     

Intern Med. (2018, 57(1): 1-12)

Okamura, K. Shirai, K. Okuda, T. Urata, H.

 

Improvement of Diurnal Blood Pressure Variation by Azilsartan.                                     

J Clin Med Res. (2018, 10(1): 41-49)

Okamura, K. Shirai, K. Okuda, T. Urata, H.

 

Prospective single-arm observational study of human chymase inhibitor Polygonum hydropiper L in subjects with hypertension.                                                                                 

Clin Exp Hypertens. (2018, 23: 1-9)

Okamura, K. Kuroda, R. Nagata, K. Urata, H.

 

Investigation of a Dipeptidyl Peptidase-4 Inhibitor/Thiazolidinedione Combination Drug for Patients With Type 2 Diabetes and Poor Glycemic Control: Difficulty With Patient Enrollment.       

J Clin Med Res. (2019, 11(2): 89-97)

Okamura, K. Shirai, K. Miyazaki, M. Okuda, T. Takamiya, Y. Goto, M. Urata, H.

 

Increase of chymase-dependent angiotensin II-forming activity in circulating mononuclear leukocytes after acute myocardial infarction chymase activity after acute myocardial infarction.          

Heart Vessels. 2019 Jul;34(7):1148-1157.

Okamura, K. Okuda, T. Shirai, K. Urata, H.

 

High Fib4 index in patients with suspected NASH is associated with elevation of chymase-dependent angiotensin II-forming activity in circulating mononuclear leucocytes.

Heart Vessels. 2019 Sep;34(9):1559-1569.

Okamura, K. Okuda, T. Takamiya, Y. Shirai, K. Urata, H.

 

 

First Author以外

 

Combined treatment with statin and angiotensin-receptor blocker after stenting as a useful strategy for prevention of coronary restenosis. 

J Cardiol. (2005, 45(3):107-113)

Nishikawa, H. Miura, S. Shimomura, H. Tsujita, K. Okamura, K. Zhang, B. Iwata, A. Shirai, K. Matsuo, K. Arai, H. Saku, K.

 

アゼルニジピンのLDLに対する抗酸化作用 キャピラリー電気泳動法による評価Prog.Med. (2006, 26(7): 1661-1664)

谷川宏之, 三浦伸一郎, 岡村圭祐, 西川宏明, 上原吉就, 張波, 朔啓二郎

 

冠攣縮性狭心症患者の長期予後に及ぼすCa拮抗薬と硝酸薬併用の効果

Prog.Med. (2009, 29(3): 831-837)

三好恵、井上裕紀子、児玉直、角俊一郎、岡村圭祐、新村英也、安藤知恵、 山之内良雄、浦田秀則

 

Additive antihypertensive and antihypertrophic effects of long-acting Ca blockers in uncontrolled hypertensive patients with angiotensin-receptor blocker based treatment

Int Heart J (2009, 50(5): 555-570)

Kodama, S. Inoue, Y. Miyoshi, K. Sumi, S. Okamura, K. Tojo, H. Ando, C. Niimura, H. Tsuchiya, Y. Mihara, H. Yamanouchi, Y. Urata, H.

 

Beneficial effect of combination therapy comprising angiotensin receptor blocker plus calcium channel blocker on plasma adiponectin levels                                                                   

Clin Exp Hypertension (2010, 32(1): 21-28)

Inoue, Y. Kakuma, T. Nonaka, Y. Sumi, S. Okamura, K. Kodama, S. Ando, C. Niimura, H. Miyoshi, K. Tsuchiya, Y. Yamanouchi, Y. Urata, H.

 

管理不良高血圧症例でのイルベサルタンの有効降圧と安全性 多施設共同前向き観察研究CHAT-A1y (Chikushi Anti-hypertension Trial-Avapro) 

血圧 (2012, 19(10): 912-922)

松本研三, 角俊一郎, 高宮陽介, 岡村圭祐, 森憲, 北島研, 久保田和充, 東條秀明, 浦田秀則

 

Differential Action of Four Long Acting Calcium Channel Blockers on Heart Rate and Renal Function

Therapeutic Research (2013, 34(1): 93-104)

Tojo, H. Sumi, S. Okuda, T. Arimura, T. Okamura, K. Matsumoto, K. Takamiya, Y. Mitsutake, R. Kitajima, K. Mori, K. Saku, K. Urata, H.

 

Effect of Angiotensin-Converting Enzyme Inhibitor/Calcium Antagonist Combination Therapy on Renal Function in Hypertensive Patients With Chronic Kidney Disease: Chikushi Anti-Hypertension Trial – Benidipine and Perindopril.                             

J Clin Med Res. (2018, 10(2): 117-124)

Okuda, T. Okamura, K. Shirai, K. Urata, H.

 

Association between medication adherence and illness perceptions in atrial fibrillation patients treated with direct oral anticoagulants: An observational cross-sectional pilot study.

PLoS One. 2018 Sep 28;13(9)

Miyazaki, M. Nakashima, A. Nakamura, Y. Sakamoto, Y. Matsuo, K. Goto, M. Uchiyama, M. Okamura, K. Mitsutake, R. Urata, H. Kamimura, H. Imakyure, O.

 

Multicenter prospective observational study of teneligliptin, a selective dipeptidyl peptidase-4 inhibitor, in patients with poorly controlled type 2 diabetes: Focus on glycemic control, hypotensive effect, and safety Chikushi Anti-Diabetes Mellitus Trial-Teneligliptin (CHAT-T).

Clin Exp Hypertens. 2019 Apr 11:1-8.

Takamiya, Y. Okamura, K. Shirai, K. Okuda, T. Kobayashi, K. Urata, H.

症例報告

First Author

 

ALP anomaly(IgGλchainとの結合)を認めた一例            

臨牀と研究 (2004, 81 (7): 1187-1188)

岡村圭祐, 三浦伸一郎, 朔錦, 朔啓二郎

 

ヒト心房性ナトリウム利尿ペプチドの単独投与により人工呼吸器管理を回避できた心不全の一例        

臨牀と研究 (2005, 82 (9): 1585-1588)

岡村圭祐, 西川宏明, 三浦伸一郎, 朔啓二郎

 

一般旅客機を使用した転院の構想から搬送の実際まで (致死性不整脈による心肺停止蘇生後症例での経験より)        

臨床と研究 (2017, 94 (9): 1140-1147)

岡村圭祐, 奥田哲, 平塚裕也, 猿渡恵子, 重金勇太, 小渕弥生,  山田摂子, 原田信子, 渡邉直美, 久保伸子, 江頭好美, 山本たも, 下村武司, 葉瀬垣光, 松尾邦浩, 白井和之, 浦田秀則

 

Ventricular Septal Perforation after Acute Myocardial Infarction with Severe Inflammation: Three Case Reports

福岡大学医学紀要 (2017, 44 (2): 91-96)

Okamura Keisuke, Mori Etsuo, Nakamura Toshihiro

 

Persistent Primary Aldosteronism Despite Iatrogenic Adrenal Hemorrhage After Adrenal Vein Sampling.   

J Clin Med Res. (2018, 10(1): 66-71)

Okamura K, Okuda T, Shirai K, Abe I, Kobayashi K, Ishii T, Haraoka S, Urata H.

 

Reduction of Blood Pressure Following After Renal Artery Adventitia Stripping During Total Nephroureterectomy: Potential Effect of Renal Sympathetic Denervation.                        

Okamura K, Satou S, Setojima K, Shono S, Miyajima S, Ishii T, Shirai K, Urata H.

Am J Case Rep. (2018, 19: 567-572)

 

海外からの旅行客の心肺停止、急性心筋梗塞症例を経験して急増する訪日観光客への対応     

臨牀と研究 (2018, 95 (11): 1254-1258)

岡村圭祐, 奥田哲, 安部大介, 谷口裕美, 重金勇太, 猿渡恵子, 山田摂子, 渡邉直美, 松尾邦浩, 白井和之, 浦田秀則

 

A Case of Primary Aldosteronism Due to A Primary Adrenal Adenoma Diagnosed by Segmental Adrenal Venous Sampling (S-AVS) Using a Modified Catheter System and Lateral Cine Angiography.      

Am J Case Rep. (2019, 20: 139-145)

Okamura K, Okuda T, Fukuda Y, Takamiya Y, Shirai K, Miyajima S, Ishii T, Urata H.

 

 

First Author以外

 

Successful Intensive Lipid-lowering Therapy Using Atorvastatin Stabilizes Coronary Artery Plaque as Assessed by Multi-detector Row Computed Tomography

Internal Medicine (2007, 46 (12): 859-863)

Mitsutake Ryoko, Miura Shin-ichiro, Okamura Keisuke, Niimura Hideya, Kawamura Akira, Saku Keijiro

 

A case of primary aldosteronism who experienced cardiopulmonary arrest, was resuscitated and cured

Journal of Cardiology Cases (2014, 9 (2): 63–66)

Yosuke Takamiya, Ken Kitajima, Kazumitsu Kubota, Kenzo Matsumoto, Shunichiro Sumi, Keisuke Okamura, Ken Mori, Hideaki Tojo, Keijiro Saku, Hidenori Urata

 

Two Years Efficacy of Paclitaxel-Coated Balloon Dilation for In-Stent Renal Artery Restenosis Due to Takayasu Arteritis.

Am J Case Rep. 2019 Jul 25;20:1089-1093.

Yamamoto T, Shirai K, Okamura K, Urata H.

総説

First Author

 

レニン・アンジオテンシン・アルドステロン(RAA)系のホットスポット 心不全心臓のカタストロフィーにキマーゼとRAA系はどのように関与しているか             

血圧(2012, 19 (1): 32-37)

岡村圭祐, 浦田秀則

 

【腎デナベーションの今】交感神経とレニンアンジオテンシン系はどう関連するか?

Heart View (2015, 19(5): 490-494)

岡村圭祐, 浦田秀則

 

Anticipated expansion of a new approach to treating hypertension without medication by catheter-based renal denervation.       

J Thorac Dis. (2018, 10(26): 3266-3270)

Okamura K, Urata H.

 

 

First Author以外

 

収縮機能が低下した心不全の血圧管理

これだけは知っておきたい日常診療で遭遇する心血管合併症を有する高血圧の管理 (2016: 73-75)

奥田哲, 岡村圭祐, 浦田秀則

 

【心血管病予防における機能性食品の役割】正常高値からI度高血圧症例でのヒトキマーゼ抑制を介した紅タデスプラウト服用降圧作用

機能性食品と薬理栄養 (2016, 10 (3): 108-112)

浦田秀則, 黒田理恵子, 芳賀慶一郎, 奥田哲, 岡村圭祐, 井手はるみ, 遠竹奈央, 田邉カオリ

その他

Letter, Correspondence

 

Changes in total lipid profiles assessed by analytical capillary isotachophoresis throughout the acute phase of myocardial infarction

Int J Cardiol. (2006, 108(2): 264-266)

Okamura K, Miura S, Zhang B, Nishikawa H, Matsuo K, Shirai K, Saku K.

 

Simplifying adrenal vein sampling for cardiologists “In the New Era of Catheter Treatment for Hypertension”.             

Hypertens Res. (2019, 42(1): 117-119)

Okamura K, Urata H.

 

Observation of renal sympathetic nerves by intravascular ultrasound.  

Hypertens Res. 2019 Jul;42(7):1092-1094.

Satou S, Okamura K, Konishi R, Shirai K, Urata H.

賞罰

101回日本循環器学会九州地方会若手研究者賞

2006年12月

 

The Poster Award Committee of the European Society of Hypertension London Meeting 2012 

(22nd European Meeting on hypertension and cardiovascular protection)